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Ashish Kumar Sharma,Akash Sharma,Rita Kumari,Kunal Kishore,Divya Sharma,Bharthu Parthsarthi Srinivasan,Ashok Sharma,Santosh Kumar Singh,Samir Gaur,Vijay Singh Jatav,Prashant Sharma,Varnika Srivastava,Sneha Joshi,Megha Joshi,Prashant Kumar Dhakad,Davender Singh Kanawat,Akanksha Mishra,Anil Sharma,Dharmendra Singh,Ravinder Pal Singh,Himmat Singh Chawda,Rambir Singh,Sachin Kumar Raikwar,Muneem Kumar Kurmi,Pankaj Khatri,Ashutosh Agarwal,Arshee Munajjam.Journal of Biomedical Research,2012,26(3):200-210
Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats
Received:May 09, 2011  
DOI10.7555/JBR.26.20110054
Keywordsdiabetic neuropathy, nicotinamide-streptozotocin, metformin, pioglitazone, glimipiride, sitagliptin, amitriptyline
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AuthorInstitution
Ashish Kumar Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Akash Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Rita Kumari Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Kunal Kishore Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Divya Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Bharthu Parthsarthi Srinivasan Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences & Research, Pushpvihar, New Delhi , India
Ashok Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Santosh Kumar Singh Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Samir Gaur Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Vijay Singh Jatav Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Prashant Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Varnika Srivastava Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Sneha Joshi Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Megha Joshi Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Prashant Kumar Dhakad Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Davender Singh Kanawat Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Akanksha Mishra Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Anil Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Dharmendra Singh Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Ravinder Pal Singh Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Himmat Singh Chawda Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Rambir Singh Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Sachin Kumar Raikwar Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Muneem Kumar Kurmi Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Pankaj Khatri Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India
Ashutosh Agarwal Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences & Research, Pushpvihar, New Delhi , India
Arshee Munajjam Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur Rajasthan , India;Department of Pharmacology, Kota Collage of Pharmacy, RIICO Industrial Area, Ranpur, Kota Rajasthan, Pincode , Ind
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Abstract
      Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neuropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide-streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly improved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 (P < 0.001). Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 (P < 0.001). Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.
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