• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
Current Issue             Journal of Biomedical Research--2017, 31(6)
Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins
Vassilis I. Zannis,Shi Su,Panagiotis Fotakis
In this review, we focus on the pathway of biogenesis of HDL, the essential role of apoA-I, ATP binding cassette transporter A1 (ABCA1), and lecithin: cholesterol acyltransferase (LCAT) in the formation of plasma HDL; the generation of aberrant forms of HDL containing mutant apoA-I forms and the rol...more>>
J Biomed Res 2017;31(6):471-485.   doi:10.7555/JBR.31.20160082
Effective doctor-patient communication skills training optimizes functional organization of intrinsic brain architecture: a restingstate functional MRI study
Bing Zhang,Ling Ni,Fangfang Wang,Weiping Li,Xin Zhang,Xiaohua Gu,Zuzana Nedelska,Fei Chen,Kun Wang,Bin Zhu,Renyuan Liu,Jun Xu,Jinfan Wang
We studied the influence of doctor-patient communication skills training on brain functional architecture using resting-state functional MRI (rs-fMRI) with a regional homogeneity (ReHo) method. Ten medical students participated in the study. A 1-year long doctor-patient communication skills training...more>>
J Biomed Res 2017;31(6):486-493.   doi:10.7555/JBR.31.20160135
Proteomic analysis of the dorsal spinal cord in the mouse model of spared nerve injury-induced neuropathic pain
Eun-sung Park,Jung-mo Ahn,Sang-min Jeon,Hee-jung Cho,Ki-myung Chung,Je-yoel Cho,Dong-ho Youn
Peripheral nerve injury often causes neuropathic pain and is associated with changes in the expression of numerous proteins in the dorsal horn of the spinal cord. To date, proteomic analysis method has been used to simultaneously analyze hundreds or thousands of proteins differentially expressed in ...more>>
J Biomed Res 2017;31(6):494-502.   doi:10.7555/JBR.31.20160122
Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity
Jieun Choi,Eun Suk An,Young-Hwan Ban,Da Woom Seo,Tae-Su Kim,Sung-Pyo Lee,You Lin,Ehn-Kyoung Choi,Yun-Bae Kim
Particulate matters (PM) are one of the major body burdens leading to diseases. We investigated the capacities of a hydrogen-enriched water (HW) eliminating carbon nanoparticles (CNP) and carbon microparticles (CMP) from the lungs and blood, respectively. In CNP-elimination test, rats were orally ad...more>>
J Biomed Res 2017;31(6):503-511.   doi:10.7555/JBR.31.20170066
Pigment epithelium derived factor (PEDF) prevents methyl methacrylate monomer-induced cytotoxicity in H9c2 cells
Li Xin,Tian Han,Jiao Tang,Xiaoyu Wang,Hao Zhang,Hongyan Dong,Kaijin Guo,Zhongming Zhang
Acrylic bone cements are currently the most frequently and extensively used materials in orthopedic implant treatment. However, adverse effects have been described of acrylic bone cement on the cardiovascular system. In the present study, we examined the cytotoxicity of bone cement ingredient methyl...more>>
J Biomed Res 2017;31(6):512-520.   doi:10.7555/JBR.31.20170068
Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats
Alireza Shirpoor,Farzaneh Hosseini Gharalari,Yousef Rasmi,Elaheh Heshmati
Chronic ethanol consumption is associated with changes in the function and structure of the lungs. The aim of this study was to investigate the effect of chronic ethanol exposure on the lungs and whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats. Male Wistar rats we...more>>
J Biomed Res 2017;31(6):521-527.   doi:10.7555/JBR.31.20160151
Profiles of metabolic gene expression in the white adipose tissue, liver and hypothalamus in leptin knockout (LepΔI14/ΔI14 ) rats
Leijian Guan,Kaixuan Xu,Shuyang Xu,Ningning Li,Xinru Wang,Yankai Xia,Di Wu
Leptin deficiency is principally linked to metabolic disorders. Leptin knockout (LepΔI14/ΔI14) Sprague Dawley rats created by CRISPR/Cas9 is a new model to study metabolic disorders. We used a whole rat genome oligonucleotide microarray to obtain tissue-specific gene expression profiles of the white...more>>
J Biomed Res 2017;31(6):528-540.   doi:10.7555/JBR.31.20170021
Nighttime snacking is associated with risk of obesity and hyperglycemia in adults: a cross-sectional survey from Chinese adult teachers
Xiaoyang Liu,Chunlin Zheng,Cheng Xu,Qian Liu,Jin Wang,Yongzhi Hong,Peng Zhao
Relationship between nighttime snack and human health conditions remains unclear. In this paper, we analyzed the association of frequency of nighttime snacking with obesity, hyperlipidemia and hyperglycemia using a Chinese teacher cohort. The Chinese teacher study contains 22,176 of the general adul...more>>
J Biomed Res 2017;31(6):541-547.   doi:10.7555/JBR.31.20160083
Semi-automated carotid lumen segmentation in computed tomography angiography images
Hamid Reza Hemmati,Mahdi Alizadeh,Alireza Kamali-Asl,Shapour Shirani
Carotid artery stenosis causes narrowing of carotid lumens and may lead to brain infarction. The purpose of this study was to develop a semi-automated method of segmenting vessel walls, surrounding tissues, and more importantly, the carotid artery lumen by contrast computed tomography angiography (C...more>>
J Biomed Res 2017;31(6):548-558.   doi:10.7555/JBR.31.20160107
Vanishing cerebral vasculitis in a patient with Lewy pathology
Natalia Liapounova,Kamran H. Azar,J. Max Findlay,Jian-Qiang Lu
Immune-mediated mechanisms are involved in the pathogenesis of both cerebral vasculitis and Parkinson's disease (PD, brainstem-predominant Lewy pathology), but the presentation of cerebral vasculitis with comorbid Lewy pathology has not yet been reported. Here we present a case of pathologically con...more>>
J Biomed Res 2017;31(6):559-562.   doi:10.7555/JBR.31.20160119
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