• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
Current Issue             Journal of Biomedical Research--2017, 31(3)
Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers
Anam Akhtar,Scarlet Xiaoyan Wang,Lucy Ghali,Celia Bell,Xuesong Wen
Since arsenic trioxide was first approved as the front line therapy for acute promyelocytic leukemia 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of arsenic trioxide in treating hematological cancers have not...more>>
J Biomed Res 2017;31(3):177-188.   doi:10.7555/JBR.31.20160059
The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer
Kevin Lee,Gary A Piazza
The activation of the Wnt/β-catenin signaling cascade has been well studied and documented in colorectal cancer (CRC). The long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to reduce the incidence and risk of death from CRC in numerous epidemiological studies. The NSAID ...more>>
J Biomed Res 2017;31(3):189-196.   doi:10.7555/JBR.31.20160133
Perioperative “remote” acute lung injury: recent update
Zhaosheng Jin,Ka Chun Suen,Daqing Ma
Perioperative acute lung injury (ALI) is a syndrome characterised by hypoxia and chest radiograph changes. It is a serious post-operative complication, associated with considerable mortality and morbidity. In addition to mechanical ventilation, remote organ insult could also trigger systemic respons...more>>
J Biomed Res 2017;31(3):197-212.   doi:10.7555/JBR.31.20160053
Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis
Xu Hu,Linfei Jiang,Chenhui Tang,Yuehong Ju,Li Jiu,Yongyue Wei,Li Guo,Yang Zhao
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants of ESR1 in association with breast cancer susceptibility. We performed a meta-ana...more>>
J Biomed Res 2017;31(3):213-225.   doi:10.7555/JBR.31.20160087
Genetic variation of the PSCA gene (rs2294008) is not associated with the risk of prostate cancer
Il-Seok Lee,Sung Pil Seo,Yun Sok Ha,Pildu Jeong,Ho Won Kang,Won Tae Kim,YongJune Kim,Seok Joong Yun,Sang Cheol Lee,Wun-Jae Kim
Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids and highly expressed in the prostate, but there have been few reports on the relationship between rs2294008 of PSCA and prostate cancer in the literature. Therefore, we evaluated the association between r...more>>
J Biomed Res 2017;31(3):226-231.   doi:10.7555/JBR.31.20160072
Ginkgol C17:1 inhibits tumor growth by blunting the EGF-PI3K/Akt signaling pathway
Yueying Li,Jun Liu,Xiaoming Yang,Yan Dong,Yali Liu,Min Chen
Ginkgol C17:1 has been shown to inhibit apoptosis and migration of cancer cells, but the underlying mechanisms are not fully elucidated. In this study, we explored whether the inhibitory effects of Ginkgol C17:1 were associated with epidermal growth factor receptor (EGFR) and PI3K/Akt signaling. The...more>>
J Biomed Res 2017;31(3):232-239.   doi:10.7555/JBR.31.20160039
Modeling and validating three dimensional human normal cervix and cervical cancer tissues in vitro
Anna Karolina Zuk,Xuesong Wen,Stephen Dilworth,Dong Li,Lucy Ghali
The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies. The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue. Normal epithelial and immortalized cervical epithelial ca...more>>
J Biomed Res 2017;31(3):240-247.   doi:10.7555/JBR.31.20160150
Insensitivity of PI3K/Akt/GSK3 signaling in peripheral blood mononuclear cells of age-related macular degeneration patients
Xunxian Liu,Zemin Yao
Our recent studies with cultured retinal pigment epithelium cells suggested that overexpression of interleukin 17 receptor C (IL-17RC), a phenomenon observed in peripheral blood and chorioretinal tissues with age-related macular degeneration (AMD), was associated with altered activation of phosphati...more>>
J Biomed Res 2017;31(3):248-255.   doi:10.7555/JBR.31.20160096
Electromyography and Fos immunostaining study establish a possible functional link between trigeminal proprioception and the oculomotor system in rats
Houcheng Liang,Jingdong Zhang,Pifu Luo,Hongna Zhu,Ying Qiao,Anle Su,Ting Zhang
The objective of this study was to explore whether there was a functional link between trigeminal proprioception and the oculomotor system mediated through jaw muscle afferents. Electromyography (EMG) was undertaken of the levator palpebrae (LP) and superior rectus (SR), and Fos expression was detec...more>>
J Biomed Res 2017;31(3):256-263.   doi:10.7555/JBR.31.20160127
Setting kinetics and mechanical properties of flax fibre reinforced glass ionomer restorative materials
Ensanya Ali Abou Neel,Anne M. Young
Regardless of the excellent properties of glass ionomer cements, their poor mechanical properties limit their applications to non-load bearing areas. This study aimed to investigate the effect of incorporated short, chopped and randomly distributed flax fibers (0, 0.5, 1, 2.5, 5 and 25 wt%) on setti...more>>
J Biomed Res 2017;31(3):264-272.   doi:10.7555/JBR.31.20150023
Spindle cell carcinoma of the mandible: a case report
Long Xie,Heming Wu,Siyu Liu,Hongwei Li
Spindle cell carcinoma is a rare highly malignant squamous cell carcinoma. Here, we describe a case of a 74-yearold Chinese female who presented with a 2-week history of pain and swelling in the left retromolar region. Surgical resection and titanium plate prosthesis were performed and histological ...more>>
J Biomed Res 2017;31(3):273-276.   doi:10.7555/JBR.30.20140061
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