• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
Current Issue             Journal of Biomedical Research--2018, (1)
PERSPECTIVE
Human parvovirus B19-associated hematopathy in HIV disease: need for clinicopathological revisit
Idris Abdullahi Nasir,Jessy Thomas Medugu,Amos Dangana

J Biomed Res 2018;(1):1-2.   doi:10.7555/JBR.32.2017010
REVIEW ARTICLES
Transforming growth factor-β signaling in systemic sclerosis
Nolan B. Ayers,Chenming Sun,Shi-You Chen
Systemic sclerosis (SSc) is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the antigen-specific immune system and the non-specific immune system, resulting in autoanti...more>>
J Biomed Res 2018;(1):3-12.   doi:10.7555/JBR.31.20170034
Oxidized phospholipids and lipoprotein-associated phospholipase A2 as important determinants of Lp(a) functionality and pathophysiological role
Alexandros D. Tselepis
Lipoprotein(a) [Lp(a)] is composed of a low density lipoprotein (LDL)-like particle to which apolipoprotein (a) [apo(a)] is linked by a single disulfide bridge. Lp(a) is considered a causal risk factor for ischemic cardiovascular disease (CVD) and calcific aortic valve stenosis (CAVS). The evidence ...more>>
J Biomed Res 2018;(1):13-22.   doi:10.7555/JBR.31.20160009
ORIGINAL ARTICLES
Sample size re-estimation without un-blinding for time-to-event outcomes in oncology clinical trials
Lihong Huang,Jianling Bai,Hao Yu,Feng Chen
Sample size re-estimation is essential in oncology studies. However, the use of blinded sample size reassessment for survival data has been rarely reported. Based on the density function of the exponential distribution, an expectation-maximization (EM) algorithm of the hazard ratio was derived, and ...more>>
J Biomed Res 2018;(1):23-29.   doi:10.7555/JBR.31.20160111
Safety of axitinib and sorafenib monotherapy for patients with renal cell carcinoma: a meta-analysis
Fei Qin,Hao Yu,Changrong Xu,Huihui Chen,Jianling Bai
We sought to investigate safety of axitinib or sorafenib in renal cell carcinoma (RCC) patients and compare toxicity of these two vascular endothelial growth factor receptor inhibitors. Databases of PubMed and Embase were searched. We included phase II and III prospective trials, as well as retrospe...more>>
J Biomed Res 2018;(1):30-38.   doi:10.7555/JBR.32.20170080
Dietary crocin reverses melanoma metastasis
Hamid A Bakshi,Faruck Lukmanul Hakkim,Smitha Sam,Farideh Javid,Luay Rashan
Crocus sativus and its bioactive constituent crocin are well known for anti-tumor potential in different models. However, the efficacy of crocin on in-vivo melanoma metastasis is not yet reported. In this study, melanoma metastatic model was developed by tail vein injection of B16F-10 cells in to C5...more>>
J Biomed Res 2018;(1):39-50.   doi:10.7555/JBR.31.20160120
Effects of a soybean milk product on feto-neonatal development in rats
Eun Suk An,Dongsun Park,Young-Hwan Ban,Jieun Choi,Da Woom Seo,Yoon Bok Lee,Mi Yae Shon,Ehn-Kyoung Choi,Yun-Bae Kim
Since estrogenic pollutants and phytoestrogens can cause the disorder of the reproductive system, the effects of a soybean milk product (Vegemil? containing 162 ppm isoflavones) on the feto-neonatal development, including male reproductive function, were investigated. Pregnant rats were fed the soyb...more>>
J Biomed Res 2018;(1):51-57.   doi:10.7555/JBR.31.20170067
Interference with the C-terminal structure of MARF1 causes defective oocyte meiotic division and female infertility in mice
Guangyi Cao,Mingzhe Li,Hao Wang,Lanying Shi,You-Qiang Su
The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510150, China; 3Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai 200433, China; 4Key Laboratory of Model Animal Research, Nanjing Medical University, Nanjing, Jiangsu 211166, Chin...more>>
J Biomed Res 2018;(1):58-67.   doi:10.7555/JBR.32.20170108
CASE REPORT
Cervical spine fractures in osteopetrosis: a case report and review of the literature
Arjang Ahmadpour,Amir Goodarzi,Darrin J. Lee,Ripul R. Panchal,Kee D. Kim
While management of appendicular fractures has been well described in the setting of osteopetrosis, there is limited information on managing fractures of the axial spine. Here we present an osteopetrotic patient with multiple traumatic multiple, comminuted, unstable cervical spinal fractures managed...more>>
J Biomed Res 2018;(1):68-76.   doi:10.7555/JBR.32.20170055
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