• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
Current Issue             Journal of Biomedical Research--2017, 31(3)
PERSPECTIVE
REVIEW ARTICLES
Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers
Anam Akhtar,Scarlet Xiaoyan Wang,Lucy Ghali,Celia Bell,Xuesong Wen
Since arsenic trioxide was first approved as the front line therapy for acute promyelocytic leukemia 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of arsenic trioxide in treating hematological cancers have not...more>>
J Biomed Res 2017;31(3):177-188.   doi:10.7555/JBR.31.20160059
The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer
Kevin Lee,Gary A Piazza
The activation of the Wnt/β-catenin signaling cascade has been well studied and documented in colorectal cancer (CRC). The long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to reduce the incidence and risk of death from CRC in numerous epidemiological studies. The NSAID ...more>>
J Biomed Res 2017;31(3):189-196.   doi:10.7555/JBR.31.20160133
Perioperative “remote” acute lung injury: recent update
Zhaosheng Jin,Ka Chun Suen,Daqing Ma
Perioperative acute lung injury (ALI) is a syndrome characterised by hypoxia and chest radiograph changes. It is a serious post-operative complication, associated with considerable mortality and morbidity. In addition to mechanical ventilation, remote organ insult could also trigger systemic respons...more>>
J Biomed Res 2017;31(3):197-212.   doi:10.7555/JBR.31.20160053
ORIGINAL ARTICLES
Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis
Xu Hu,Linfei Jiang,Chenhui Tang,Yuehong Ju,Li Jiu,Yongyue Wei,Li Guo,Yang Zhao
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants of ESR1 in association with breast cancer susceptibility. We performed a meta-ana...more>>
J Biomed Res 2017;31(3):213-225.   doi:10.7555/JBR.31.20160087
Genetic variation of the PSCA gene (rs2294008) is not associated with the risk of prostate cancer
Il-Seok Lee,Sung Pil Seo,Yun Sok Ha,Pildu Jeong,Ho Won Kang,Won Tae Kim,YongJune Kim,Seok Joong Yun,Sang Cheol Lee,Wun-Jae Kim
Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids and highly expressed in the prostate, but there have been few reports on the relationship between rs2294008 of PSCA and prostate cancer in the literature. Therefore, we evaluated the association between r...more>>
J Biomed Res 2017;31(3):226-231.   doi:10.7555/JBR.31.20160072
Ginkgol C17:1 inhibits tumor growth by blunting the EGF-PI3K/Akt signaling pathway
Yueying Li,Jun Liu,Xiaoming Yang,Yan Dong,Yali Liu,Min Chen
Ginkgol C17:1 has been shown to inhibit apoptosis and migration of cancer cells, but the underlying mechanisms are not fully elucidated. In this study, we explored whether the inhibitory effects of Ginkgol C17:1 were associated with epidermal growth factor receptor (EGFR) and PI3K/Akt signaling. The...more>>
J Biomed Res 2017;31(3):232-239.   doi:10.7555/JBR.31.20160039
Modeling and validating three dimensional human normal cervix and cervical cancer tissues in vitro
Anna Karolina Zuk,Xuesong Wen,Stephen Dilworth,Dong Li,Lucy Ghali
The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies. The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue. Normal epithelial and immortalized cervical epithelial ca...more>>
J Biomed Res 2017;31(3):240-247.   doi:10.7555/JBR.31.20160150
Insensitivity of PI3K/Akt/GSK3 signaling in peripheral blood mononuclear cells of age-related macular degeneration patients
Xunxian Liu,Zemin Yao
Our recent studies with cultured retinal pigment epithelium cells suggested that overexpression of interleukin 17 receptor C (IL-17RC), a phenomenon observed in peripheral blood and chorioretinal tissues with age-related macular degeneration (AMD), was associated with altered activation of phosphati...more>>
J Biomed Res 2017;31(3):248-255.   doi:10.7555/JBR.31.20160096
Electromyography and Fos immunostaining study establish a possible functional link between trigeminal proprioception and the oculomotor system in rats
Houcheng Liang,Jingdong Zhang,Pifu Luo,Hongna Zhu,Ying Qiao,Anle Su,Ting Zhang
The objective of this study was to explore whether there was a functional link between trigeminal proprioception and the oculomotor system mediated through jaw muscle afferents. Electromyography (EMG) was undertaken of the levator palpebrae (LP) and superior rectus (SR), and Fos expression was detec...more>>
J Biomed Res 2017;31(3):256-263.   doi:10.7555/JBR.31.20160127
Setting kinetics and mechanical properties of flax fibre reinforced glass ionomer restorative materials
Ensanya Ali Abou Neel,Anne M. Young
Regardless of the excellent properties of glass ionomer cements, their poor mechanical properties limit their applications to non-load bearing areas. This study aimed to investigate the effect of incorporated short, chopped and randomly distributed flax fibers (0, 0.5, 1, 2.5, 5 and 25 wt%) on setti...more>>
J Biomed Res 2017;31(3):264-272.   doi:10.7555/JBR.31.20150023
CASE REPORT
Spindle cell carcinoma of the mandible: a case report
Long Xie,Heming Wu,Siyu Liu,Hongwei Li
Spindle cell carcinoma is a rare highly malignant squamous cell carcinoma. Here, we describe a case of a 74-yearold Chinese female who presented with a 2-week history of pain and swelling in the left retromolar region. Surgical resection and titanium plate prosthesis were performed and histological ...more>>
J Biomed Res 2017;31(3):273-276.   doi:10.7555/JBR.30.20140061
Authors and Reviewers
SCImago Journal & Country Rank
Journal Services
Early Releases
Newsletters
Top Journal Content
  • Leishmania donovani whole cell antigen delivered with adjuvants protects against visceral leishmaniasis in vervet monkeys (Chlorocebus aethiops)(3613)
  • Epidural abscess after multiple lumbar punctures for labour epidural catheter placement(3075)
  • Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats(2931)
  • Role of remote sensing, geographic bioinformatics system and bioinformatics in kala-azar epidemiology(2912)
  • The expression and localization of a novel protein phosphatase inhibitor 2810408A11Rik in mouse testis and sperm(2906)
  • Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model(2885)
  • Induced pluripotent stem cells are induced pluripotent stem cell-like cells(2806)
  • Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience(2801)
  • UVB suppresses PTEN expression by upregulating miR-141 in HaCaT cells(2797)
  • Flotillin-2 is an acrosome-related protein involved in mouse spermiogenesis(2694)
  • Current perspectives of nanoparticles in medical and dental biomaterials(2656)
  • Single-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers(2622)
  • Clostridium difficile infections in China(2546)
  • Dual therapy of rosiglitazone/pioglitazone with glimepiride on diabetic nephropathy in experimentally induced type 2 diabetes rats(2456)
  • Atrial fibrillation(2334)
  • Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium(2309)
  • Lipoprotein metabolism in nonalcoholic fatty liver disease(2288)
  • Effects of infusion of different fluids during controlled hypotension on gastric intramucosal pH and postoperative gastroenterological function(2229)
  • Anisocoria in a 10-month old girl in the immediate preoperative setting: can you proceed with surgery?(2129)
  • Mycobacterium tuberculosis using statistical coupling analysis of the esterase family proteins(2107)
  • Secondary metabolite credentials of Evolvulus alsinoides by high performance thin layer chromatography (HPTLC)(2100)
  • MiR-148a inhibits angiogenesis by targeting ERBB3(2080)
  • Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells(2075)
  • Fracture resistance of posterior teeth restored with modern restorative materials(2065)
  • Comparative domain modeling of human EGF-like module EMR2 and study of interaction of the fourth domain of EGF with chondroitin 4-sulphate(2037)
  • Reduction of G0 phase cells of colon cancer caco-2 cells may enhance 5-fluorouracil efficacy(2029)
  • Sinomenine reduces iNOS expression via inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats(1982)
  • The MDM2-p53 pathway revisited(1957)
  • Cryptosporidiosis-an overview(1930)
  • Successful conservative management with methotrexate and mifepristone of cervical pregnancy(1920)
  •    External Links
    .