Title: Effects of Chemotherapeutic Agent Bendamustin for Non-Hodgkin Lymphoma on Spermatogenesis in Mouse


Authors: Minbo Zang, Qiao Zhou, Yunfei Zhu, Mingxi Liu, Zuomin Zhou


Institution: State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 211166, China


Abstract: Non-Hodgkin lymphoma (NHL) is one of the most common cancer affecting men of reproductive age. The high response rate of bendamustine served as first-line treatment for NHL, coupled with young age of patients, makes elucidation of the impact of treatment on male reproduction important. Our aim is to determine the effects of bendamustine on the male reproduction by animal model. Male mice were treated with bendamustin (40 mg/kg) through tail vein injection while cis-plain was as a standard (3 mg/kg) through intraperitoneal injection. After 3 weeks, we found that bendmustine induced weight loss and sperm morphology abnormalities compared to the control. Additionally, the sperm with folded tails were the most frequent abnormality in bendamustine-treated mice. But the mechanism of sperm abnormality induced by bendamustine remains to be elucidated. These results indicate bendamustine may affect spermatozoa of patients who have been treated for Non-Hodgkin lymphoma.


Keywords: Non-Hodgkin lymphoma, Chemotherapy, Bendamustine, Mice, Spermatozoa, Toxicology


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J Biomed Res published on 18 May, 2017, doi:10.7555/JBR.31.20170023