Title: The effect of sunblock against oxidative stress in farmers: a pilot study

Authors: Yong-Dae Kim1,2, Dong-Hyuk Yim1,2, Sang-Yong Eom1,2, Ji Yeoun Lee1,3, Heon Kim1,2

Institutions: 1 Center for Farmers’ Safety and Health, Chungbuk National University Hospital, Cheongju, Republic of Korea; 2Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea; 3Department of Dermatology, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.

Abstract: Farmers are frequently exposed to ultraviolet (UV) radiation which causes various diseases by inducing oxidative mstress. This study aimed to assess the effects of sunblock on oxidative stress in the body. Eighty-seven farmers were divided into two groups: those who wore sunblock for five days and those who did not. The total antioxidant capacity (TAC) in urine, which is an antioxidant indicator, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in urine, an oxidative stress indicator, were measured. The urinary TAC of sunblock users was significantly higher than that of non-users, but urinary 8-OHdG levels were not significantly different. Even after adjustment for potential confounders, urinary TAC was found to be markedly increased with sunblock usage. These results suggest that sunblock is effective in preventing oxidative stress among farmers. In addition, they show that urinary TAC can be used as a good effect marker of oxidative stress caused by UV exposure.

Keywords: farmers, ultraviolet rays, sunscreening agents, oxidative stress, total antioxidant capacity

Full Text:  jbr-2016-0092.pdf

J Biomed Res published on November 12th, 2016, doi:10.7555/JBR.31.20160092