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Natalia Liapounova,Kamran H. Azar,J. Max Findlay,Jian-Qiang Lu.Journal of Biomedical Research,2017,31(6):559-562
Vanishing cerebral vasculitis in a patient with Lewy pathology
Received:September 20, 2016  
Keywords£ºvasculitis, cerebrovascular disease, Parkinson's disease, Lewy pathology, synucleinopathy, immune pathogenesis
Grant Program£ºThe authors thank Dr. Robert A. Ashforth, radiologist at the University of Alberta Hospital, for his help with interpreting MR images, and Dr. Marius Meyer, family physician in Dawson Creek, British Columbia, for the patient care and providing additional clinical information.
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Natalia Liapounova Division of Pediatric Neurology, University of Alberta, Edmonton, Alberta, Canada
Kamran H. Azar Department of Pathology, The North East Health Services Delivery Area, Fort St. John, British Columbia, Canada;
J. Max Findlay Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada
Jian-Qiang Lu Neuropathology Section, Department of Laboratory Medicine and Pathology, University of Alberta, University of Alberta, Edmonton, Alberta, Canada
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Abstract £º
      Immune-mediated mechanisms are involved in the pathogenesis of both cerebral vasculitis and Parkinson's disease (PD, brainstem-predominant Lewy pathology), but the presentation of cerebral vasculitis with comorbid Lewy pathology has not yet been reported. Here we present a case of pathologically confirmed vasculitis in a 73-year-old male patient whose postmortem examination revealed Lewy pathology diagnostic of PD. This case study suggests a comorbidity of cerebral vasculitis and Lewy pathology, as well as potential pathogenic interactions between these two disorders with immune-mediated mechanisms.