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Jieun Choi,Eun Suk An,Young-Hwan Ban,Da Woom Seo,Tae-Su Kim,Sung-Pyo Lee,You Lin,Ehn-Kyoung Choi,Yun-Bae Kim.Journal of Biomedical Research,2017,31(6):503-511
Hydrogen-enriched water eliminates fine particles from thelungs and blood by enhancing phagocytic activity
Received:June 21, 2017  
DOI10.7555/JBR.31.20170066
Keywordsparticulate matter, pneumoconiosis, hydrogen-enriched water, particle clearance, antioxidation
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Jieun Choi College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Eun Suk An College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Young-Hwan Ban College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Da Woom Seo College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Tae-Su Kim Anydoctor Healthcare Co., Ltd., Cheonan, Chungnam, Republic of Korea
Sung-Pyo Lee Anydoctor Healthcare Co., Ltd., Cheonan, Chungnam, Republic of Korea
You Lin Hotan Dichen Medicine Biotechnology Co., Ltd., Hotan, Xinjiang, China
Ehn-Kyoung Choi College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Yun-Bae Kim College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
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Abstract
      Particulate matters (PM) are one of the major body burdens leading to diseases. We investigated the capacities of a hydrogen-enriched water (HW) eliminating carbon nanoparticles (CNP) and carbon microparticles (CMP) from the lungs and blood, respectively. In CNP-elimination test, rats were orally administered with purified water (PW) or HW (10 or 30 mL/kg/day) for 10 weeks. At the time point of 4 weeks, the rats were challenged with intratracheal instillation of CNP (4 mg). CNP accumulated in the airways and alveoli, and induced inflammatory lesions. Such pneumoconiosis was markedly improved by feeding HW, while PW was ineffective. CNP-induced pneumoconiosis caused systemic hematological alterations, decreasing major inflammatory cells, but markedly increasing eosinophils, indicative of an allergic reaction, which were attenuated by treatment with HW. Such PM-eliminating and antiallergic effects of HW reduced body burden as confirmed from the facilitated recovery of body and lung weights. In CMP-clearance test, mice were orally administered with PW or HW for 7 days, and intravenously injected with CMP (300 mg/kg). CMP was rapidly eliminated from the blood in HW-fed mice. Indeed, the phagocytic indices increased to 3.5 and 6.7 folds at 10 and 30 mL/kg of HW, in comparison with a negligible effect of PW. As a mechanism study, only HW significantly inhibited lipid peroxidation in vitro Fenton reaction-mediated $OH-generating system. Collectively, the results indicate that HW not only effectively eliminated PM from the lungs and blood by enhancing phagocytic activity, but also attenuated the lung injuries by inhibiting lipid peroxidation.
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