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Oluyomi Stephen Adeyemi,Cincin Sokolayemji Aroge,Musbau Adewumi Akanji2.Journal of Biomedical Research,2017,31(4):350-357
Moringa oleifera-based diet protects against nickel-induced hepatotoxicity in rats
Received:April 22, 2016  Revised:March 27, 2016
DOI£º10.7555/JBR.31.20160051
Keywords£ºdiet supplement, hepatoprotective, metal toxicity, Moringa oleifera
Grant Program£º
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AuthorInstitution
Oluyomi Stephen Adeyemi Medicinal Biochemistry and Toxicology Laboratory, Department of Biological Sciences, Landmark University, Omu- Aran, Kwara State, Nigeria
Cincin Sokolayemji Aroge Medicinal Biochemistry and Toxicology Laboratory, Department of Biological Sciences, Landmark University, Omu- Aran, Kwara State, Nigeria
Musbau Adewumi Akanji2 Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
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Abstract £º
      Multiple health-promoting effects have been attributed to the consumption of Moringa oleifera leaves, as part of diet without adequate scientific credence. This study evaluated the effect of M. oleifera-based diets on nickel (Ni) - induced hepatotoxicity in rats. Male rats assigned into six groups were given oral administration of 20 mg/kg body weight nickel sulfate in normal saline and either fed normal diet or M. oleifera-based diets for 21 days. All animals were sacrificed under anesthesia 24 hours after the last treatment. Ni exposure elevated the rat plasma activities of alanine transaminase, aspartate transaminase and alkaline phosphatase significantly. Ni exposure also raised the levels of triglyceride, total cholesterol and low-density lipoprotein cholesterol while depleting the high-density lipoprotein cholesterol concentration. Further, Ni exposure raised rat plasma malondialdehyde but depleted reduced glutathione concentrations. The histopathological presentations revealed inflammation and cellular degeneration caused by Ni exposure. We show evidence that M. oleifera-based diets protected against Ni-induced hepatotoxicity by improving the rat liver function indices, lipid profile as well as restoring cellular architecture and integrity. Study lends credence to the health-promoting value of M. oleifera as well as underscores its potential to attenuate hepatic injury.
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