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Lei Chang,Chun-Yu Yin,Hai-Yin Wu,Bin-Bin Tian,Yan Zhu,Chun-Xia Luo,Dong-YaZhu.Journal of Biomedical Research,2017,31(4):306-314
(+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines
Received:November 23, 2016  Revised:December 08, 2016
DOI10.7555/JBR.31.20160138
Keywords(+)-borneol, neuroprotective effects, permanent cerebral ischemia, anti-inflammation, functional recovery, dendritic spines
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AuthorInstitution
Lei Chang Institution of Stem Cells and Neuroregeneration, Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu , China
Chun-Yu Yin Institution of Stem Cells and Neuroregeneration, Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu , China
Hai-Yin Wu Institution of Stem Cells and Neuroregeneration, Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu , China
Bin-Bin Tian Institution of Stem Cells and Neuroregeneration, Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu , China
Yan Zhu Institution of Stem Cells and Neuroregeneration, Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu , China
Chun-Xia Luo Institution of Stem Cells and Neuroregeneration, Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu , China
Dong-YaZhu Institution of Stem Cells and Neuroregeneration, Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu , China;The Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing, Jiangsu , China
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Abstract
      Stroke is one of the leading causes of disability and death globally. It occurs when a major artery is occluded in the brain and leads to death of cells within the injured tissue. (+)-Borneol, a simple bicyclic monoterpene extracted from traditional Chinese medicine, is widely used in various types of diseases. However, no study has proved the effects of (+)-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown. Here, we report that in the rat model of permanent cerebral ischemia, we found that (+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scores via reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-a) in a dose dependent manner. Notably, (+)-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. These findings suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke.
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