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Il-Seok Lee,Sung Pil Seo,Yun Sok Ha,Pildu Jeong,Ho Won Kang,Won Tae Kim,YongJune Kim,Seok Joong Yun,Sang Cheol Lee,Wun-Jae Kim.Journal of Biomedical Research,2017,31(3):226-231
Genetic variation of the PSCA gene (rs2294008) is not associated with the risk of prostate cancer
Received:June 06, 2016  Revised:July 05, 2016
DOI10.7555/JBR.31.20160072
Keywordsprostatic neoplasms, polymorphism, genetic, risk, prostate, polymorphism, single nucleotide
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Il-Seok Lee Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
Sung Pil Seo Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
Yun Sok Ha Department of Urology, School of Medicine, Kyungpook National University, Daegu 700-422, South Korea
Pildu Jeong Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
Ho Won Kang Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
Won Tae Kim Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
YongJune Kim Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
Seok Joong Yun Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
Sang Cheol Lee Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
Wun-Jae Kim Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-711, South Korea
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Abstract
      Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids and highly expressed in the prostate, but there have been few reports on the relationship between rs2294008 of PSCA and prostate cancer in the literature. Therefore, we evaluated the association between rs2294008 and the risk of prostate cancer. A total of 240 prostate cancer patients and 306 controls (patients with benign prostatic hyperplasia) were enrolled. Genotype analysis of rs2294008 of PSCA was performed using PCR. Logistic regression analysis was performed according to the genotype of PSCA rs2294008. We found that CT and TT genotypes were associated with an insignificant risk of prostate cancer compared with the CC genotype (P = 0.627 and 0.397, respectively). In addition, there was no significant difference in rs2294008 according to clinicopathological parameters, such as age, Gleason score, prostate-specific antigen (PSA), stage, and metastasis in prostate cancer (P > 0.05 for each). Age, Gleason score, PSA, pathologic stage, and metastasis did not modify the association between PSCA and the risk of prostate cancer (each P > 0.05 for each). Taken together, the genetic polymorphism of PSCA rs2294008 was not associated with the risk of prostate cancer. Our results suggest that rs2294008 may not play a role in prostate carcinogenesis.
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