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Xu Hu,Linfei Jiang,Chenhui Tang,Yuehong Ju,Li Jiu,Yongyue Wei,Li Guo,Yang Zhao.Journal of Biomedical Research,2017,31(3):213-225
Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis
Received:July 23, 2016  Revised:September 25, 2016
DOI10.7555/JBR.31.20160087
Keywordsbreast cancer, estrogen receptor alpha, meta-analysis, single nucleotide polymorphism
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Xu Hu Department of Biotechnology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu , China
Linfei Jiang Department of Biotechnology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu , China
Chenhui Tang Department of Biotechnology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu , China
Yuehong Ju Department of Biotechnology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu , China
Li Jiu School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu , China
Yongyue Wei Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu , China
Li Guo School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu , China
Yang Zhao Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu , China
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Abstract
      Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants of ESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms of ESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype. For rs2046210, the AA, GA, or GA + GG genotype had a much higher risk compared to the GG genotype. No significant association was found for the rs1801132 polymorphism with breast cancer risk. This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms of ESR1 and breast cancer risk. The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.
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