CiteULike  View Full Text   View/Add Comment  Download reader    
Zhaosheng Jin,Ka Chun Suen,Daqing Ma.Journal of Biomedical Research,2017,31(3):197-212
Perioperative ¡°remote¡± acute lung injury: recent update
Received:April 28, 2016  Revised:June 01, 2016
DOI£º10.7555/JBR.31.20160053
Keywords£ºacute lung injury, intraoperative care/adverse effects, postoperative complications, inflammation, anesthetics, general, fluid therapy
Grant Program£º
¡¡¡¡ ¡¡¡¡ ¡¡¡¡
AuthorInstitution
Zhaosheng Jin Anaesthetics, Pain Medicine and intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London SW10 9NH, UK
Ka Chun Suen Anaesthetics, Pain Medicine and intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London SW10 9NH, UK
Daqing Ma Anaesthetics, Pain Medicine and intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London SW10 9NH, UK
Hits: 107
Download times: 80
      
Abstract £º
      Perioperative acute lung injury (ALI) is a syndrome characterised by hypoxia and chest radiograph changes. It is a serious post-operative complication, associated with considerable mortality and morbidity. In addition to mechanical ventilation, remote organ insult could also trigger systemic responses which induce ALI. Currently, there are limited treatment options available beyond conservative respiratory support. However, increasing understanding of the pathophysiology of ALI and the biochemical pathways involved will aid the development of novel treatments and help to improve patient outcome as well as to reduce cost to the health service. In this review we will discuss the epidemiology of peri-operative ALI; the cellular and molecular mechanisms involved on the pathological process; the clinical considerations in preventing and managing perioperative ALI and the potential future treatment options.
Close