CiteULike  View Full Text   View/Add Comment  Download reader    
Gang Niu,Xuewen Yu,Jian Yang,Rong Wang,Shaojuan Zhang,Youmin Guo.Journal of Biomedical Research,2011,25(3):197-203
Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience
  
DOI£ş10.1016/S1674-8301(11)60026-2
Keywords£şintervertebral lumbar disc, apparent diffusion coefficient, disc bulging, disc herniation
Grant Program£ş
ĦĦĦĦ ĦĦĦĦ ĦĦĦĦ ĦĦĦĦ ĦĦĦĦ ĦĦĦĦ
AuthorInstitution
Gang Niu Department of Diagnostic Radiology, the First Hospital of Medical School, XiĦŻan Jiaotong University, XiĦŻan, Shaanxi , China
Xuewen Yu Department of Diagnostic Radiology, the First Hospital of Medical School, XiĦŻan Jiaotong University, XiĦŻan, Shaanxi , China
Jian Yang Department of Diagnostic Radiology, the First Hospital of Medical School, XiĦŻan Jiaotong University, XiĦŻan, Shaanxi , China
Rong Wang Department of Diagnostic Radiology, the First Hospital of Medical School, XiĦŻan Jiaotong University, XiĦŻan, Shaanxi , China
Shaojuan Zhang Department of Diagnostic Radiology, the First Hospital of Medical School, XiĦŻan Jiaotong University, XiĦŻan, Shaanxi , China
Youmin Guo Department of Diagnostic Radiology, the First Hospital of Medical School, XiĦŻan Jiaotong University, XiĦŻan, Shaanxi , China
Hits: 2802
Download times: 1173
      
Abstract £ş
      The aim of the present study was to compare the relationship of morphologically defined non-bulging/herni-ated, bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient (ADC). Thirty-two healthy volunteers and 28 patients with back pain or sciatica were examined by MRI. All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades. The ADC values of nucleus pulposus (NP) were measured and recorded. The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs (P < 0.05), whereas there were no significant differences in ADC values between bulging and herniated discs (P > 0.05). Moreover, statistically significant relationship was found in the mean ADC values of NP between "non-bulging/herniated and non-degenerated discs" and "non-bulging/herniated degenerated discs" as well as herniated discs (P < 0.05). Linear regression analysis between ADC value and disc level revealed an inverse correlation (r = -0.18). The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities.
Close