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Ke Jin,Shixia Wang,Zuhu Huang,Shan Lu.Journal of Biomedical Research,2010,24(6):411-416
Clostridium difficile infections in China
Received:July 19, 2010  
DOI£º10.1016/S1674-8301(10)60055-3
Keywords£ºClostridium difficile, review, prevalence, incidence, risk factors
Grant Program£º
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AuthorInstitution
Ke Jin Department of Infectious Diseases/Jiangsu Province Key Laboratory in Infectious Diseases/China-US Vaccine Research Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu , China
Shixia Wang China-US Vaccine Research Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu , China/Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Zuhu Huang Department of Infectious Diseases/Jiangsu Province Key Laboratory in Infectious Diseases/China-US Vaccine Research Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu , China
Shan Lu Jiangsu Province Key Laboratory in Infectious Diseases/China-US Vaccine Research Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu , China/Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
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Abstract £º
      Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection in Chinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem of over-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potential risk factors that may contribute to C. difficile infection in China. A literature review of available published studies, including those in Chinese language-based journals, was conducted. A review of the currently available literature suggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliable epidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries.
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