CiteULike  View Full Text   View/Add Comment  Download reader  Relevent Materials:   JBR-2014-0045_supplementary.pdf  
Lotte Jacobs,Lutgarde Thijs,Yu Jin,Faiez Zannad,Alexandre Mebazaa,Philippe Rouet,Florence Pinet,Christophe Bauters,Burkert Pieske,Andreas Tomaschitz,Mamas Mamas,Javier Diez,Kenneth McDonald,John G F Cleland,Hans-Peter Brunner-La Rocca,Stephane Heymans,Roberto Latini,Serge Masson,Peter Sever,Christian Delles,Stuart Pocock,Timothy Collier,Tatiana Kuznetsova,Jan A Staessen,On behalf of the Heart ¡®omics¡¯ in AGEing (HOMAGE) investigators.Journal of Biomedical Research,2014,28(5):349-359
Heart ¡®omics¡¯ in AGEing (HOMAGE): design, research objectives and characteristics of the common database
Received:March 08, 2014  Revised:March 31, 2014
DOI£º10.7555/JBR.28.20140045
Keywords£ºleft ventricle, heart failure, heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, population science, morbidity, mortality
Grant Program£º
¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡ ¡¡¡¡
AuthorInstitution
Lotte Jacobs Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
Lutgarde Thijs Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
Yu Jin Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
Faiez Zannad Centre d'Investigation Clinique Pierre Drouin and U 961, Hypertension and Heart Failure Unit, Institut Lourrain du Coeur et des Vaisseaux, Inserm, Nancy, France
Alexandre Mebazaa Department of Anesthesiology and Critical Care Medicine, InsermUMR-S942, Ho? pital Lariboisie`re, Universite¡ä Paris Diderot, Paris, France
Philippe Rouet Equipe obe¡ä site¡ä et insuffisance cardiaque, Universite¡ä UPS, Inserm I2MC, UMR 1048, Toulouse, France
Florence Pinet Inserm, U744, CHRU, Lille, France
Christophe Bauters Inserm, U744, CHRU, Lille, France
Burkert Pieske Department of Cardiology, Medical University Graz, Austria
Andreas Tomaschitz Department of Cardiology, Medical University Graz, Austria
Mamas Mamas Cardiovascular Institute, University of Manchester, Manchester, UK
Javier Diez Division of Cardiovascular Sciences, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain
Kenneth McDonald Heart Failure Unit, St Vincent's University Hospital, University College Dublin, Dublin, Ireland
John G F Cleland Department of Cardiology, University of Hull, UK
Hans-Peter Brunner-La Rocca Department of Cardiology, Maastricht University Medical Centre, Netherlands
Stephane Heymans Center for Heart Failure Research, Department of Cardiology, Maastricht University, Netherlands
Roberto Latini Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche ¡®¡®Mario Negri¡¯¡¯, Milan, Italy
Serge Masson Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche ¡®¡®Mario Negri¡¯¡¯, Milan, Italy
Peter Sever International Center for Circulatory Health, Imperial College London, UK
Christian Delles Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Center, University of Glasgow, Glasgow, UK
Stuart Pocock London School of Hygiene and Tropical Medicine, London, UK
Timothy Collier London School of Hygiene and Tropical Medicine, London, UK
Tatiana Kuznetsova Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
Jan A Staessen Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
On behalf of the Heart ¡®omics¡¯ in AGEing (HOMAGE) investigators
Hits: 1708
Download times: 712
      
Abstract £º
      Heart failure is common in older people and its prevalence is increasing. The Heart ¡®omics¡¯ in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure. A large clinical database, based on (1) prospective population studies or (2) cross-sectional, prospective studies or randomized controlled trials (RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising ¡®omics¡¯-based biomarkers to identify the risk of developing heart failure and/or comorbidities. Population studies, patient cohorts and RCTs are eligible for inclusion in the common database, if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors. Currently, the HOMAGE database includes 43,065 subjects, from 20 studies in eight European countries, including healthy subjects from three population studies in France, Belgium and Italy (n=7,124), patients with heart failure (n=4,312) from four cohorts in the UK, Spain and Switzerland and patients at high risk for cardiovascular disease (n=31,629) in 13 cohorts. It is anticipated that more partners will join the consortium and enlarge the pooled data. This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.
Close