X
CiteULike  View Full Text   View/Add Comment  Download reader    
Min Zhang,Yan Zhang,Shuaishuai Zhu,Xiaoyu Li,Qing Yang,Hui Bai,Qi Chen.Journal of Biomedical Research,2012,26(6):418-424
Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese
Received: December 06, 2011  
DOI:10.7555/JBR.26.20110116
Keywordsclass A scavenger receptor gene; single nucleotide polymorphisms (SNPs); coronary artery disease; Chinese population
Grant Program
AuthorInstitution
Min Zhang Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Yan Zhang Department of Medicine, China -Japan Friendship Hospital, Beijing 100029, China 
Shuaishuai Zhu Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Xiaoyu Li Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Qing Yang Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Hui Bai Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Qi Chen Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Hits: 903
Download times: 565
      
Abstract
      The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease (CAD) in Chinese is not defined. Here, we performed an independent case-control study in a Chinese population consisting of 402 CAD cases and 400 controls by genotyping ten single nucleotide polymorphisms (SNPs) of MSR1. We found that rs416748 and rs13306541 were significantly associated with an increased risk of CAD with per allele odds ratio (OR) of 1.56 [95% confidence interval (CI) = 1.28-1.90; P < 0.001] and 1.70 (95% CI = 1.27-2.27; P < 0.001), re-spectively. Our results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of CAD in combination with traditional risk factors of CAD in Chinese population.
Close