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Peng Zou,Lin Zhao,Haitao Xu,Ping Chen,Aihua Gu,Ning Liu,Peng Zhao,Ailin Lu.Journal of Biomedical Research,2012,26(4):253-259
Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis
Received: October 24, 2011  
DOI:10.7555/JBR.26.20110122
Keywordscancer; meta-analysis; hsa-mir-499 rs3746444; polymorphism; susceptibility; miRNAs; pre-miRNA
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Peng Zou Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Lin Zhao Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Haitao Xu Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Ping Chen Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Aihua Gu State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Ning Liu Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Peng Zhao Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Ailin Lu Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China 
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Abstract
      MicroRNAs (miRNAs) are gene regulators involved in numerous diseases including cancer, heart disease, neurological disorders, vascular abnormalities and autoimmune conditions. Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer, the data have yielded conflicting results. Therefore, this meta-analysis was performed to provide a comprehensive assessment of potential association between hsa-mir-499 rs3746444 polymorphism and cancer risk. In this meta-analysis, a total of 9 articles regarding 10 eligible case-control studies in English (including 6134 cases and 7141 controls) were analyzed. No significant association between hsa-mir-499 rs3746444 polymorphism and overall cancer risk was demonstrated. However, an increased risk was observed in the subgroup of breast cancer patients (G allele vs A allele: OR = 1.10, 95% CI = 1.00-1.20; Pheterogeneity = 0.114; I2 = 53.9%) and population-based studies (G allele vs A allele: OR = 1.12, 95% CI = 1.00-1.25; Pheterogeneity = 0.062; I2 = 64.0%). The findings suggested an association be-tween hsa-mir-499 rs3746444 polymorphism and increased risk to breast cancer.
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