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Hong Xie,Chen Wang,Xuemei Wu,Xia Liu,Shigang Qiao,Chunfeng Liu,Hong Liu.Journal of Biomedical Research,2012,26(1):37-43
Parthenolide attenuates LPS-induced activation of NF-百B in a time-dependent manner in rat myocardium
Received:June 20, 2011  
DOIㄩ10.1016/S1674-8301(12)60005-0
Keywordsparthenolide, nuclear-factor-百B, lipopolysaccharide, myocardium
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Hong Xie Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou , China
Chen Wang Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou , China/Institute of Neuroscience, Soochow University, Suzhou , China
Xuemei Wu Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou , China
Xia Liu Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou , China
Shigang Qiao Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou , China
Chunfeng Liu Institute of Neuroscience, Soochow University, Suzhou , China
Hong Liu Department of Anesthesiology and Pain Medicine, University of California Davis, Davis, CA 95616, USA
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Abstract
      Parthenolide (PTN), a selective nuclear factor kappa B (NF-百B) inhibitor, has been used extensively to inhibit NF-百B activation. The duration of the inhibitory effect of PTN on NF-百B in vivo remains unclear. This study was to determine whether a lipopolysaccharide (LPS) challenge 6, 12 and 24 h after the administration of PTN could activate NF-百B. Rats were devided into five groups. The rats in the PTN, PTN+LPS and DMSO groups were in-jected intraperitoneally with PTN or DMSO. After 6, 12 or 24 h, LPS was administered in LPS and PTN+LPS groups. The expressions of NF-百B p50, I百B汐 and p-I百B汐 were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h. In summary, myocardial NF-百B expression occurs 1 h after the administration of LPS. PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo.
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